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The BIOFIRE System and Your Immune System

The BIOFIRE System offers syndromic testing for infectious diseases, allowing healthcare providers to select the right test the first time. Patients benefit from quicker diagnosis and more targeted treatments. Clinicians benefit from improved stewardship for antibiotics. Labs gain efficiency and cost savings.

The BioFire Pneumonia Plus Panel (PN panel) tests native sputum (including mini-BAL) as well as endotracheal sludge and bronchoalveolar Slurries (including mini BAL) for 33 clinically significant pathogens and resistance genes to antimicrobials within an hour.

Respiratory

The burning of biomass (wood, plants and other organic materials) creates gaseous pollutants and fine particles that negatively impact the respiratory system. Climate change may make it more difficult to reverse the negative effects of forest fires to human health.

In the United States, wildfire smoke has been associated with hospitalizations for respiratory diseases, such as asthma, COPD and lung cancer. Additionally, this kind of air pollution can be an underlying risk factor for cardiovascular disease and is a significant contributing factor to the burden of disease for the most vulnerable population, including people with lower socioeconomic status (SES).

Wildfires caused unhealthy levels of air pollution in numerous communities during the COVID-19 epidemic. The public health response has been limited to a public education campaign regarding the management of symptoms. This knowledge gap is alarming, considering the evidence that smoking and other sources of air pollution can lead to health problems.

Researchers are now looking at the best ways to protect public's health during any future events of this nature. NIH is funding research into this crucial public health issue through the BLUE CORAL study and its successor FIRE CORAL.

First time an prospective study will evaluate long-term outcomes of exposure to smoke from wildfires or other sources. FIRE CORAL is recruiting adult participants hospitalized for COVID-19's index episode who speak English or Spanish and are not pregnant. The FIRE CORAL protocol includes a series of in-person assessments objectively measuring pulmonary function testing and lung imaging as well as functional assessment.

The lungs are especially sensitive to the effects of smoke and other particles due to the fact that they can trigger or exacerbate chronic respiratory conditions such as emphysema, asthma and COPD, and increase the risk of developing pneumonia. A variety of steps can be taken to stop or lessen the negative health effects resulting from exposures to smoke, which includes abstaining from outdoor activities when it is possible and wearing the EPA's "N95" mask designed to catch fine particles.

Smoking cigarettes can cause irritation to the eyes, throat and nose. To help reduce symptoms, drink plenty of water, and take medication to reduce inflammation, such as corticosteroids.

Bloodstream

Your bloodstream is at the forefront of fighting off germs that enter your body. Special cells called dendritic cells are like your fire department's call center; they take antigens (molecules that trigger an immune response) from germs that are invading your body and then release proteins that signal other white blood cells to come to fight them. The total number of white blood cells, differentials, and band cells increased after firefighters' firefighting tasks in comparison to levels after vigorous exercise that did not include firefighting.

Skin

As the wildfires in California produced smoke and dust into the air over the course of fall and winter, dermatologists were concerned about how that could affect the skin of people exposed to it. Maria Wei, a graduate student at University of California, Irvine is researching how extreme pollution from wildfires affects the skin. Her research was published on April 22 2012 in Scientific Reports.

Wei's research has shown that the temperature of the skin changes depending on the length of time that the body is exposed to flames. It could take up to two hours for the skin of someone to reach their "flash point"--the moment at which it begins to burn and then turns ashy. This is the reason why it's essential to avoid being near the campfire or a biofuel fire, and why you should wear protective clothing if you are outside in the midst of a forest fire or even on the heat of the day.

Forest bioethanol fires near me will continue to occur, despite the measures taken to prevent fires from causing pollution. Wei is forecasting that the number of people suffering from the consequences of wildfires will increase as climate change causes more and more forests to be burned. This means that more people will have to wear long sleeves and hats and also thick moisturizers.

Air pollution from wildfires can cause atopic dermatitis to the skin, which is a condition that causes itchy skin for many people. She claims that the particles in smoke can clog pores, making atopic skin worse.

Another issue is the fact that atopic dermatitis can make people more sensitive to UV light, which can also be aggravated by smoke from wildfires. This can cause people to be more likely to visit tanning salons, and can also cause the skin to get darker with less protection than they need to.

While a cold and bioethanol fireplace indoor bio ethanol fire (Anipi-italia.org) facial can help lessen the effects of atopic skin dermatitis, it's not recommended for anyone with an open wound or a rash on their face. This treatment is not recommended for patients with active acne, or if you're pregnant or nursing. The IS Clinical Fire & Ice Facial at Novuskin, Las Vegas' premiere membership MedSpa, is an intensive result-driven facial that bridges the gap between a gentle facial and a peel without having to wait for any downtime. It's designed to smooth the skin, alleviate the appearance of rosacea, reduce acne scarring, reduce fine lines, and encourage cell renewal. It's a fantastic treatment to give yourself radiant skin.

Infections

The human body is a multi-faceted system of organs and tissues that work together to shield us from infections. Infections can be caused by microorganisms, such as bacteria, viruses and parasites which infect healthy cells, causing them to multiply uncontrollably. Your immune system can react by exhibiting symptoms of illness. These symptoms can include anything from a stuffy or runny nose to a stomach upset however, they may also include a fever high, swollen glands, and a eruption. The symptoms you experience can be affected by the nature of the infection, its location, and even your temperature.

Infections spread in many ways, but the most common are from person to person by droppings that hang in the air after coughing or sneezing. This is how bacterial diseases such as tuberculosis, strep and meningococcal illnesses and viral infections like the common cold and influenza spread. Some bacterial infections, such as skin infections and sexually transmitted diseases (STIs) like gonorrhea or chlamydia are transmitted by direct contact with infected tissue or mucous membranes or by indirect contact with surfaces that are contaminated. Certain bacterial infections are transmitted by insects, such as ticks, fleas or mosquitoes.

The virus and the parasites are small enough to get into your bloodstream and infect your cells which can cause serious illness like the common cold or AIDS. Fungi can trigger skin conditions like athlete's feet and ringworm and others can infect the respiratory system and the nervous system.

The BioFire PN Panel uses our innovative FilmArray technology to analyze a complete list of pathogens involved in upper respiratory infections in sputum or samples of bronchoalveolar fluid. The kit comes with an reagent pouch that houses all the chemistry needed to perform reverse transcription PCR, nested multiplex PCR and detection using a single machine. This is a simple method that helps clinicians identify and treat patients with a variety respiratory symptoms. This test has been given an Emergency Use Authorization. It's available in bioMerieux CLIA medium and high complexity labs.